Publications

2018

HIV-1 Vpr and p21 restrict LINE-1 mobility

K. Kawano; A. J. Doucet; M. Ueno; R. Kariya; W. An et al.

Nucleic Acids Research. 2018-07-31.

DOI : 10.1093/nar/gky688.

KAP1 facilitates reinstatement of heterochromatin after DNA replication

S. M. Jang; A. Kauzlaric; J.-P. Quivy; J. Pontis; B. Rauwel et al.

Nucleic Acids Research. 2018-06-28.

DOI : 10.1093/nar/gky580.

Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naïve embryonic stem cells

A. Coluccio; G. Ecco; J. Duc; S. Offner; P. Turelli et al.

Epigenetics & Chromatin. 2018-02-26.

DOI : 10.1186/s13072-018-0177-1.

2017

KRAB zinc finger proteins

G. Ecco; M. Imbeault; D. Trono

Development. 2017.

DOI : 10.1242/dev.132605.

A KRABsody for Embryo-Placental Development

D. Trono

Developmental Cell. 2017.

DOI : 10.1016/j.devcel.2017.06.005.

DUX-family transcription factors regulate zygotic genome activation in placental mammals

A. De Iaco; E. Planet; A. Coluccio; S. Verp; J. Duc et al.

Nature Genetics. 2017.

DOI : 10.1038/ng.3858.

Polyphenic trait promotes liver cancer in a model of epigenetic instability

M. Cassano; S. Offner; E. Planet; A. Piersigilli; S. M. Jang et al.

Hepatology. 2017.

DOI : 10.1002/hep.29182.

The mouse genome displays highly dynamic populations of KRAB-zinc finger protein genes and related genetic units

A. Kauzlaric; G. Ecco; M. Cassano; J. Duc; M. Imbeault et al.

PLoS One. 2017.

DOI : 10.1371/journal.pone.0173746.

KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks

M. Imbeault; P.-Y. Helleboid; D. Trono

Nature. 2017.

DOI : 10.1038/nature21683.

SMiLE-seq identifies binding motifs of single and dimeric transcription factors

A. Isakova; R. Groux; M. Imbeault; P. Rainer; D. Alpern et al.

Nature methods. 2017.

DOI : 10.1038/nmeth.4143.

2016

Switzerland and the Digital Health Revolution

D. Trono

Chimia. 2016.

DOI : 10.2533/chimia.2016.851.

Lentiviral vectors, two decades later

L. Naldini; D. Trono; I. M. Verma

Science. 2016.

DOI : 10.1126/science.aah6192.

Transposable Elements, Polydactyl Proteins, and the Genesis of Human-Specific Transcription Networks

D. Trono

Cold Spring Harbor symposia on quantitative biology. 2016.

DOI : 10.1101/sqb.2015.80.027573.

A Large-Scale Functional Screen to Identify Epigenetic Repressors of Retrotransposon Expression

G. Ecco; H. M. Rowe; D. Trono

Methods in molecular biology (Clifton, N.J.). 2016.

DOI : 10.1007/978-1-4939-3372-3_25.

Molecular Criteria for Defining the Naive Human Pluripotent State

T. W. Theunissen; M. Friedli; Y. He; E. Planet; R. C. O'Neil et al.

Cell stem cell. 2016.

DOI : 10.1016/j.stem.2016.06.011.

Human Hepatocyte-Derived Induced Pluripotent Stem Cells: MYC Expression, Similarities to Human Germ Cell Tumors, and Safety Issues

C. Unzu; M. Friedli; A. Bosman; M. E. Jaconi; B. E. Wildhaber et al.

Stem Cells International. 2016.

DOI : 10.1155/2016/4370142.

Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues

G. Ecco; M. Cassano; A. Kauzlaric; J. Duc; A. Coluccio et al.

Developmental Cell. 2016.

DOI : 10.1016/j.devcel.2016.02.024.

The evolution of gene expression and binding specificity of the largest transcription factor family in primates

A. Kapopoulou; L. Mathew; A. Wong; D. Trono; J. D. Jensen

Evolution. 2016.

DOI : 10.1111/evo.12819.

2015

Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages

J.-E. Dietrich; L. Panavaite; S. Gunther; S. Wennekamp; A. C. Groner et al.

EMBO reports. 2015.

DOI : 10.15252/embr.201540162.

Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch

B. Rauwel; S. M. Jang; M. Cassano; A. Kapopoulou; I. Barde et al.

eLife. 2015.

DOI : 10.7554/eLife.06068.

A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation

K. Singh; M. Cassano; E. Planet; S. Sebastian; S. M. Jang et al.

Genes & development. 2015.

DOI : 10.1101/gad.254532.114.

TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells

L. Fasching; A. Kapopoulou; R. Sachdeva; R. Petri; M. Jönsson et al.

Cell Reports. 2015.

DOI : 10.1016/j.celrep.2014.12.004.

2014

As Time Goes by: KRABs Evolve to KAP Endogenous Retroelements

M. Imbeault; D. Trono

Developmental Cell. 2014.

DOI : 10.1016/j.devcel.2014.10.019.

Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network

C. Gubelmann; P. C. Schwalie; S. K. Raghav; E. Roeder; T. Delessa et al.

Elife. 2014.

DOI : 10.7554/eLife.03346.

Dual-regulated Lentiviral Vector for Gene Therapy of X-linked Chronic Granulomatosis

M. Chiriaco; G. Farinelli; V. Capo; E. Zonari; S. Scaramuzza et al.

Molecular Therapy. 2014.

DOI : 10.1038/mt.2014.87.

Evolutionally dynamic L1 regulation in embryonic stem cells

N. Castro-Diaz; G. Ecco; A. Coluccio; A. Kapopoulou; B. Yazdanpanah et al.

Genes & development. 2014.

DOI : 10.1101/gad.241661.114.

Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements

P. Turelli; N. Castro-Diaz; F. Marzetta; A. Kapopoulou; C. Raclot et al.

Genome research. 2014.

DOI : 10.1101/gr.172833.114.

Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency

M. Friedli; P. Turelli; A. Kapopoulou; B. Rauwel; N. Castro-Díaz et al.

Genome research. 2014.

DOI : 10.1101/gr.172809.114.

Control of mitophagie by microRNAs - A key step of erythropoiesis

I. Barde; B. Rauwel; R. M. Marin-Florez; A. Corsinotti; E. Laurenti et al.

M S-Medecine Sciences. 2014.

2013

VEGFR-3 Neutralization Inhibits Ovarian Lymphangiogenesis, Follicle Maturation, and Murine Pregnancy

J. M. Rutkowski; J. E. Ihm; S. T. Lee; W. W. Kilarski; V. I. Greenwood et al.

American Journal Of Pathology. 2013.

DOI : 10.1016/j.ajpath.2013.07.031.

Prototype Foamy Virus Bet Impairs the Dimerization and Cytosolic Solubility of Human APOBEC3G

J. Vasudevan; A. Ayyappan; M. Perkovic; Y. Bulliard; K. Cichutek et al.

Journal of virology. 2013.

DOI : 10.1128/JVI.03385-12.

A switch between topological domains underlies HoxD genes collinearity in mouse limbs

G. Andrey; T. Montavon; B. Mascrez; F. Gonzalez; D. Noordermeer et al.

Science (New York, N.Y.). 2013.

DOI : 10.1126/science.1234167.

Global and stage specific patterns of krüppel-associated-box zinc finger protein gene expression in murine early embryonic cells

A. Corsinotti; A. Kapopoulou; C. Gubelmann; M. Imbeault; S. de Sio et al.

PloS one. 2013.

DOI : 10.1371/journal.pone.0056721.

Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression

C. Márquez; G. L. Poirier; M. I. Cordero; M. H. Larsen; A. Groner et al.

Transl Psychiatry. 2013.

DOI : 10.1038/tp.2012.144.

De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET

H. M. Rowe; M. Friedli; S. Offner; S. Verp; D. Mesnard et al.

Development (Cambridge, England). 2013.

DOI : 10.1242/dev.087585.

TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells

H. M. Rowe; A. Kapopoulou; A. Corsinotti; L. Fasching; T. S. Macfarlan et al.

Genome research. 2013.

DOI : 10.1101/gr.147678.112.

2012

The KRAB-ZFP/KAP1 System Contributes to the Early Embryonic Establishment of Site-Specific DNA Methylation Patterns Maintained during Development

S. Quenneville; P. Turelli; K. Bojkowska; C. Raclot; S. Offner et al.

Cell Reports. 2012.

DOI : 10.1016/j.celrep.2012.08.043.

KAP1 regulates gene networks controlling T-cell development and responsiveness

S. de Sio; R. Francesca; I. Barde; S. Offner; A. Kapopoulou et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012.

DOI : 10.1096/fj.12-206177.

MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant

M. Akerblom; R. Sachdeva; I. Barde; S. Verp; B. Gentner et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012.

DOI : 10.1523/JNEUROSCI.0558-12.2012.

Embryonic stem cell potency fluctuates with endogenous retrovirus activity

T. S. Macfarlan; W. D. Gifford; S. Driscoll; K. Lettieri; H. M. Rowe et al.

Nature. 2012.

DOI : 10.1038/nature11244.

Liver-specific ablation of Krüppel-associated box-associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma

K. Bojkowska; F. Aloisio; M. Cassano; A. Kapopoulou; F. Santoni De Sio et al.

Hepatology. 2012.

DOI : 10.1002/hep.25767.

The Kruppel-associated Box Repressor Domain Can Induce Reversible Heterochromatization of a Mouse Locus in Vivo

A. C. Groner; P. Tschopp; L. Challet; J.-E. Dietrich; S. Verp et al.

The Journal of biological chemistry. 2012.

DOI : 10.1074/jbc.M112.350884.

Gene therapy: too much splice can spoil the dish

D. Trono

The Journal of clinical investigation. 2012.

DOI : 10.1172/JCI63066.

KAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function

S. de Sio; R. Francesca; J. Massacand; I. Barde; S. Offner et al.

Blood. 2012.

DOI : 10.1182/blood-2011-12-401117.

The ATM substrate KAP1 controls DNA repair in heterochromatin: Regulation by HP1 proteins and Serine 473/824 phosphorylation

D. White; I. U. Rafalska-Metcalf; A. V. Ivanov; A. Corsinotti; H. Peng et al.

Molecular cancer research : MCR. 2012.

DOI : 10.1158/1541-7786.MCR-11-0134.

2011

A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow failure syndrome and in vivo in humanized mice

C. Frecha; C. Costa; D. Nègre; F. Amirache; D. Trono et al.

Blood. 2011.

DOI : 10.1182/blood-2011-04-346619.

In Embryonic Stem Cells, ZFP57/KAP1 Recognize a Methylated Hexanucleotide to Affect Chromatin and DNA Methylation of Imprinting Control Regions

S. Quenneville; G. Verde; A. Corsinotti; A. Kapopoulou; J. Jakobsson et al.

Molecular Cell. 2011.

DOI : 10.1016/j.molcel.2011.08.032.

A gene-rich, transcriptionally active environment and the pre-deposition of repressive marks are predictive of susceptibility to KRAB/KAP1-mediated silencing

S. Meylan; A. C. Groner; G. Ambrosini; N. Malani; S. Quenneville et al.

BMC genomics. 2011.

DOI : 10.1186/1471-2164-12-378.

Measuring In Vivo Protein Half-Life

K. Bojkowska; F. Santoni De Sio; I. Barde; S. Offner; S. Verp et al.

Chemistry & Biology. 2011.

DOI : 10.1016/j.chembiol.2011.03.014.

Lentiviral Vector Mediated Transgenesis

I. Barde; S. Verp; S. E. Offner; D. Trono

Current Protocols in Mouse Biology 1. 2011.

DOI : 10.1002/9780470942390.mo100169.

Lineage- and stage-restricted lentiviral vectors for the gene therapy of chronic granulomatous disease

I. Barde; E. Laurenti; S. Verp; M. Wiznerowicz; S. Offner et al.

Gene therapy. 2011.

DOI : 10.1038/gt.2011.65.

Chromosome Conformation Capture Uncovers Potential Genome-Wide Interactions between Human Conserved Non-Coding Sequences

D. Robyr; M. Friedli; C. Gehrig; M. Arcangeli; M. Marin et al.

PloS one. 2011.

DOI : 10.1371/journal.pone.0017634.

Profaning the Ultimate Sanctuary: HIV Latency in Hematopoietic Stem Cells

D. Trono; F. Marzetta

Cell host & microbe. 2011.

DOI : 10.1016/j.chom.2011.03.001.

Genomic instability in induced stem cells

C. E. Pasi; A. Dereli-Öz; S. Negrini; M. Friedli; G. Fragola et al.

Cell death and differentiation. 2011.

DOI : 10.1038/cdd.2011.9.

Dynamic control of endogenous retroviruses during development

H. M. Rowe; D. Trono

Virology. 2011.

DOI : 10.1016/j.virol.2010.12.007.

2010

Homology-based identification of capsid determinants that protect HIV1 from human TRIM5α restriction

P. V. Maillard; V. Zoete; O. Michielin; D. Trono

The Journal of biological chemistry. 2010.

DOI : 10.1074/jbc.M110.187609.

A systematic enhancer screen using lentivector transgenesis identifies conserved and non-conserved functional elements at the olig1 and olig2 locus

M. Friedli; I. Barde; M. Arcangeli; S. Verp; A. Quazzola et al.

PloS one. 2010.

DOI : 10.1371/journal.pone.0015741.

Structure-function analysis points to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities

Y. Bulliard; I. Narvaiza; A. Bertero; S. Peddi; U. F. Röhrig et al.

Journal of virology. 2010.

DOI : 10.1128/JVI.01651-10.

Inducible Gene and shRNA Expression in Resident Hematopoietic Stem Cells In Vivo

E. Laurenti; I. Barde; S. Verp; S. Offner; A. Wilson et al.

Stem cells (Dayton, Ohio). 2010.

DOI : 10.1002/stem.460.

Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis pigmentosa

V. Busskamp; J. Duebel; D. Balya; M. Fradot; T. J. Viney et al.

Science (New York, N.Y.). 2010.

DOI : 10.1126/science.1190897.

KRAB-Zinc Finger Proteins and KAP1 Can Mediate Long-Range Transcriptional Repression through Heterochromatin Spreading

A. C. Groner; S. Meylan; A. Ciuffi; N. Zangger; G. Ambrosini et al.

PLoS genetics. 2010.

DOI : 10.1371/journal.pgen.1000869.

The specificity of TRIM5{alpha}-mediated restriction is influenced by its coiled-coil domain

P. V. Maillard; G. Ecco; M. Ortiz; D. Trono

Journal of virology. 2010.

DOI : 10.1128/JVI.02413-09.

KAP1 controls endogenous retroviruses in embryonic stem cells

H. M. Rowe; J. Jakobsson; D. Mesnard; J. Rougemont; S. Reynard et al.

Nature. 2010.

DOI : 10.1038/nature08674.

2009

Biosafety in ex vivo gene therapy and conditional ablation of lentivirally transduced hepatocytes in nonhuman primates

O. Menzel; J. Birraux; B. E. Wildhaber; C. Jond; F. Lasne et al.

Molecular therapy : the journal of the American Society of Gene Therapy. 2009.

DOI : 10.1038/mt.2009.143.

Innate immunity against retroviral pathogens: from an ambiguous genetic self to novel therapeutic approaches

S. Meylan; D. Trono

Swiss Med Wkly. 2009.

APOBEC3G-depleted resting CD4+ T cells remain refractory to HIV1 infection

F. Santoni de Sio; D. Trono

PLoS One. 2009.

DOI : 10.1371/journal.pone.0006571.

Functional analysis and structural modeling of human APOBEC3G reveal the role of evolutionarily conserved elements in the inhibition of human immunodeficiency virus type 1 infection and Alu transposition

Y. Bulliard; P. Turelli; U. Röhrig; V. Zoete; B. Mangeat et al.

Journal of Virology. 2009.

DOI : 10.1128/JVI.01491-09.

Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications

I. Barde; E. Laurenti; S. Verp; A. C. Groner; C. Towne et al.

Journal of Virology. 2009.

DOI : 10.1128/JVI.00001-09.

2008

Antiprion prophylaxis by gene transfer of a soluble prion antagonist

N. Genoud; D. Ott; N. Braun; M. Prinz; P. Schwarz et al.

The American journal of pathology. 2008.

DOI : 10.2353/ajpath.2008.070836.

KAP1-mediated epigenetic repression in the forebrain modulates behavioral vulnerability to stress

J. Jakobsson; M. I. Cordero; R. Bisaz; A. C. Groner; V. Busskamp et al.

Neuron. 2008.

DOI : 10.1016/j.neuron.2008.09.036.

Rescue of a severe mouse model for spinal muscular atrophy by U7 snRNA-mediated splicing modulation

K. Meyer; J. Marquis; J. Trüb; R. Nlend Nelend; S. Verp et al.

Hum Mol Genet. 2008.

DOI : 10.1093/hmg/ddn382.

Development and characterization of a triple combination gene therapy vector inhibiting HIV-1 multiplication

M. Asparuhova; I. Barde; D. Trono; K. Schranz; D. Schümperli

J Gene Med. 2008.

DOI : 10.1002/jgm.1238.

A human TRIM5alpha B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus

F. Diaz-Griffero; M. Perron; K. McGee-Estrada; R. Hanna; P. V. Maillard et al.

Virology. 2008.

DOI : 10.1016/j.virol.2008.05.008.

Characterization of APOBEC3G binding to 7SL RNA

D. Bach; S. Peddy; B. Mangeat; A. Lakkaraju; K. Strub et al.

Retrovirology. 2008.

DOI : 10.1186/1742-4690-5-54.

Genotypic features of lentivirus transgenic mice

M.-O. Sauvain; A. P. Dorr; B. Stevenson; A. Quazzola; F. Naef et al.

Journal of virology. 2008.

DOI : 10.1128/JVI.00623-08.

APOBEC3-independent interferon-induced viral clearance in hepatitis B virus transgenic mice

P. Turelli; A. Liagre-Quazzola; B. Mangeat; S. Verp; S. Jost et al.

Journal of Virology. 2008.

DOI : 10.1128/JVI.00216-08.

2007

Model Structure of Human APOBEC3G

K.-L. Zhang; B. Mangeat; M. Ortiz; V. Zoete; D. Trono et al.

PLoS ONE. 2007.

DOI : 10.1371/journal.pone.0000378.

Lentivirus as a tool for lineage-specific gene manipulations

A. Malashicheva; B. Kanzler; E. Tolkunova; D. Trono; A. Tomilin

genesis. 2007.

DOI : 10.1002/dvg.20313.

Molecular mechanism of hepcidin deficiency in a patient with juvenile hemochromatosis

A. Rideau; B. Mangeat; T. Matthes; D. Trono; P. Beris

Haematologica. 2007.

DOI : 10.3324/haematol.10545.

Inhibition of HIV-1 multiplication by a modified U7 snRNA inducing Tat and Rev exon skipping

M. B. Asparuhova; G. Marti; S. Liu; F. Serhan; D. Trono et al.

The journal of gene medicine. 2007.

DOI : 10.1002/jgm.1027.

Expression of FGF-2 in neural progenitor cells enhances their potential for cellular brain repair in the rodent cortex

A. G. Dayer; B. Jenny; M.-O. Sauvain; G. Potter; P. Salmon et al.

Brain : a journal of neurology. 2007.

DOI : 10.1093/brain/awm200.

Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha

P. Maillard; S. Reynard; F. Serhan; P. Turelli; D. Trono

PLOS Pathogens. 2007.

DOI : 10.1371/journal.ppat.0030200.

The KRAB repressor domain can trigger de novo promoter methylation during mouse early embryogenesis

M. Wiznerowicz; J. Jakobsson; J. Szulc; S. Liao; A. Quazzola et al.

Journal of Biological Chemistry. 2007.

DOI : 10.1074/jbc.M705898200.

Induction of antiviral cytidine deaminases does not explain the inhibition of hepatitis B virus replication by interferons

S. Jost; P. Turelli; B. Mangeat; U. Protzer; D. Trono

J. Virol.. 2007.

DOI : 10.1128/JVI.02489-06.

2006

Ataxia-telangiectasia-mutated (ATM) protein can enhance human immunodeficiency virus type 1 replication by stimulating Rev function

Y. Ariumi; D. Trono

Journal of Virology. 2006.

DOI : 10.1128/JVI.80.5.2445-2452.2006.

Ex vivo lentivirus transduction and immediate transplantation of uncultured hepatocytes for treating hyperbilirubinemic Gunn rat

T. H. Nguyen; J. Birraux; B. Wildhaber; A. Myara; F. Trivin et al.

Transplantation. 2006.

DOI : 10.1097/01.tp.0000234675.56598.35.

Multipotential nestin and Isl-1 positive mesenchymal stem cells isolated from human pancreatic islets

M. Eberhardt; P. Salmon; M.-A. von Mach; J. G. Hengstler; M. Brulport et al.

Biochemical and Biophysical Research Communications. 2006.

DOI : 10.1016/j.bbrc.2006.05.016.

Differentiation of Trophoblast Giant Cells and Their Metabolic Functions Are Dependent on Peroxisome Proliferator-Activated Receptor  /

K. Nadra; S. I. Anghel; E. Joye; N. S. Tan; S. Basu-Modak et al.

Molecular and Cellular Biology. 2006.

DOI : 10.1128/MCB.26.8.3266-3281.2006.

A versatile tool for conditional gene expression and knockdown

J. Szulc; M. Wiznerowicz; M.-O. Sauvain; D. Trono; P. Aebischer

Nature Methods. 2006.

DOI : 10.1038/nmeth846.

Tuning silence: conditional systems for RNA interference

M. Wiznerowicz; J. Szulc; D. Trono

Nature Methods. 2006.

DOI : 10.1038/nmeth914.

Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach

A. Fodor; C. Harel; L. Fodor; M. Armoni; P. Salmon et al.

Diabetologia. 2006.

DOI : 10.1007/s00125-006-0509-8.

KRAB can repress lentivirus proviral transcription independently of integration site

Y. Bulliard; M. Wiznerowicz; I. Barde; D. Trono

The Journal of Biological Chemistry. 2006.

DOI : 10.1074/jbc.M602843200.

The integrase interactor 1 (INI1) proteins facilitate Tat-mediated human immunodeficiency virus type 1 transcription

Y. Ariumi; F. Serhan; P. Turelli; A. Telenti; D. Trono

Retrovirology. 2006.

2005

A simple and highly effective method for the stable transduction of uncultured porcine hepatocytes using lentiviral vector

T. H. Nguyen; T. Khakhoulina; A. Simmons; P. Morel; D. Trono

Cell Transplantation. 2005.

DOI : 10.3727/000000005783982828.

Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes

T. Nguyen; G. Mai; P. Villiger; J. Oberholzer; P. Salmon et al.

Journal of Hepatology. 2005.

DOI : 10.1016/j.jhep.2005.05.036.

Therapeutic lentivirus-mediated neonatal in vivo gene therapy in hyperbilirubinemic Gunn rats

T. H. Nguyen; M. Bellodi-Privato; D. Aubert; V. Pichard; A. Myara et al.

Molecular therapy : the journal of the American Society of Gene Therapy. 2005.

DOI : 10.1016/j.ymthe.2005.06.482.

Lentiviral vectors and antiretroviral intrinsic immunity

B. Mangeat; D. Trono

Human Gene Therapy. 2005.

DOI : 10.1089/hum.2005.16.913.

Harnessing HIV for therapy, basic research and biotechnology

M. Wiznerowicz; D. Trono

Trends Biotechnol. 2005.

DOI : 10.1016/j.tibtech.2004.11.001.

Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocytes

G. Mai; N. T. Huy; P. Morel; J. Mei; D. Bosco et al.

Transplant Proc. 2005.

DOI : 10.1016/j.transproceed.2005.01.017.

Editing at the crossroad of innate and adaptive immunity

P. Turelli; D. Trono

Science. 2005.

DOI : 10.1126/science.1105964.

DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration

Y. Ariumi; P. Turelli; M. Masutani; D. Trono

J Virol. 2005.

DOI : 10.1128/JVI.79.5.2973-2978.2005.

Development of cellular models for ribosomal protein S19 (RPS19)-deficient diamond-blackfan anemia using inducible expression of siRNA against RPS19

K. Miyake; J. Flygare; T. Kiefer; T. Utsugisawa; J. Richter et al.

Mol Ther. 2005.

DOI : 10.1016/j.ymthe.2004.12.001.

Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins

C. Arnaud; F. Burger; S. Steffens; N. R. Veillard; T. H. Nguyen et al.

Arterioscler Thromb Vasc Biol. 2005.

DOI : 10.1161/01.ATV.0000163840.63685.0c.

Deficiency of ribosomal protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia

J. Flygare; T. Kiefer; K. Miyake; T. Utsugisawa; I. Hamaguchi et al.

Blood. 2005.

DOI : 10.1182/blood-2004-08-3115.

Transduction of CpG DNA-stimulated primary human B cells with bicistronic lentivectors

K. Kvell; T. H. Nguyen; P. Salmon; F. Glauser; C. Werner-Favre et al.

Molecular Therapy. 2005.

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Novel lentiviral vectors displaying "early acting cytokines" selectively promote survival and transduction of NOD/SCID repopulating human hematopoietic stem cells

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Blood. 2005.

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Oncogenesis Following Delivery of a Nonprimate Lentiviral Gene Therapy Vector to Fetal and Neonatal Mice

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Molecular Therapy. 2005.

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2004

APOBEC3G Genetic Variants and Their Influence on the Progression to AIDS

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A single amino acid determinant governs the species-specific sensitivity of APOBEC3G to Vif action

B. Mangeat; P. Turelli; S. Liao; D. Trono

J Biol Chem. 2004.

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author reply on comment on: Inhibition of hepatitis B virus replication by APOBEC3G

P. Turelli; B. Mangeat; S. Jost; S. Vianin; D. Trono

science. 2004.

Response to Comment on "Inhibition of Hepatitis B Virus Replication by APOBEC3G"

P. Turelli; S. Jost; B. Mangeat; D. Trono

Science. 2004.

Inhibition of hepatitis B virus replication by APOBEC3G

P. Turelli; B. Mangeat; S. Jost; S. Vianin; D. Trono

Science. 2004.

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Contribution of proteoglycans to human immunodeficiency virus type 1 brain invasion

M. D. Bobardt; P. Salmon; L. Wang; J. D. Esko; D. Gabuzda et al.

J Virol. 2004.

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ARF1 regulates Nef-induced CD4 degradation

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Current Biology. 2004.

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Retroviruses under editing crossfire: a second member of the human APOBEC3 family is a Vif-blockable innate antiretroviral factor

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EMBO Rep. 2004.

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Entry and transcription as key determinants of differences in CD4 T-cell permissiveness to human immunodeficiency virus type 1 infection

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J Virol. 2004.

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Lentivirus-mediated RNA interference of DC-SIGN expression inhibits human immunodeficiency virus transmission from dendritic cells to T cells

J.-F. Arrighi; M. Pion; M. Wiznerowicz; T. B. Geijtenbeek; E. Garcia et al.

J Virol. 2004.

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The innate antiretroviral factor APOBEC3G does not affect human LINE-1 retrotransposition in a cell culture assay

P. Turelli; S. Vianin; D. Trono

J Biol Chem. 2004.

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Lentiviral vectors interfering with virus-induced CD4 down-modulation potently block human immunodeficiency virus type 1 replication in primary lymphocytes

H. M. Pham; E. R. Argañaraz; B. Groschel; D. Trono; J. Lama

Journal of Virology. 2004.

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2003

Lentivirus-mediated transduction of connexin cDNAs shows level- and isoform-specific alterations in insulin secretion of primary pancreatic beta-cells

D. Caton; A. Calabrese; C. Mas; V. Serre-Beinier; A. Charollais et al.

J Cell Sci. 2003.

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Hide, shield and strike back: how HIV-infected cells avoid immune eradication

B. M. Peterlin; D. Trono

Nat Rev Immunol. 2003.

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Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis

N.-B. Woods; A. Muessig; M. Schmidt; J. Flygare; K. Olsson et al.

Blood. 2003.

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Efficient transduction of primary human B lymphocytes and nondividing myeloma B cells with HIV-1-derived lentiviral vectors

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Blood. 2003.

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IL-7 surface-engineered lentiviral vectors promote survival and efficient gene transfer in resting primary T lymphocytes

E. Verhoeyen; V. Dardalhon; O. Ducrey-Rundquist; D. Trono; N. Taylor et al.

Blood. 2003.

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Activity analysis of housekeeping promoters using self-inactivating lentiviral vector delivery into the mouse retina

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Gene Ther. 2003.

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Ectopic expression of the beta-cell specific transcription factor Pdx1 inhibits glucagon gene transcription

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Diabetologia. 2003.

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Virology. Picking the right spot.

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Science. 2003.

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Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

B. Mangeat; P. Turelli; G. Caron; M. Friedli; L. Perrin et al.

Nature. 2003.

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Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference

M. Wiznerowicz; D. Trono

J Virol. 2003.

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Lentivector-mediated transfer of Bmi-1 and telomerase in muscle satellite cells yields a duchenne myoblast cell line with long-term genotypic and phenotypic stability

C. Cudré-Mauroux; T. Occhiodoro; S. König; P. Salmon; L. Bernheim et al.

Human Gene Therapy. 2003.

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2002

Efficient gene transfer into human primary blood lymphocytes by surface-engineered lentiviral vectors that display a T cell-activating polypeptide

M. Maurice; E. Verhoeyen; P. Salmon; D. Trono; S. J. Russell et al.

Blood. 2002.

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Differentiation of the RN33B cell line into forebrain projection neurons after transplantation into the neonatal rat brain

C. Lundberg; U. Englund; D. Trono; A. Björklund; K. Wictorin

Exp Neurol. 2002.

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Transepithelial transport of HIV-1 by M cells is receptor-mediated

G. Fotopoulos; A. Harari; P. Michetti; D. Trono; G. Pantaleo et al.

Proc Natl Acad Sci U S A. 2002.

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Highly efficient lentiviral vector-mediated transduction of nondividing, fully reimplantable primary hepatocytes

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Mol Ther. 2002.

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Lentiviral vectors pseudotyped with a modified RD114 envelope glycoprotein show increased stability in sera and augmented transduction of primary lymphocytes and CD34+ cells derived from human and nonhuman primates

V. Sandrin; B. Boson; P. Salmon; W. Gay; D. Nègre et al.

Blood. 2002.

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Modalities of interleukin-7-induced human immunodeficiency virus permissiveness in quiescent T lymphocytes

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Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization

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J Virol. 2002.

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The HIV-1 Nef protein and phagocyte NADPH oxidase activation

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2001

Lentiviral-mediated gene transfer into haematopoietic stem cells

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Journal of Internal Medicine -Oxford-. 2001.

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Living in oblivion: HIV immune evasion

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Semin Immunol. 2001.

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Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication

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Mol Cell. 2001.

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Transduction of CD34+ cells with lentiviral vectors enables the production of large quantities of transgene-expressing immature and mature dendritic cells

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J Gene Med. 2001.

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Inhibition of HIV-1 in cell culture by oligonucleotide-loaded nanoparticles

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Pharm Res. 2001.

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2000

Lentivirus vector gene expression during ES cell-derived hematopoietic development in vitro

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HIV-based vectors: getting the best out of the worst

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Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease

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Hum Gene Ther. 2000.

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Lentiviral vectors: turning a deadly foe into a therapeutic agent

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The Nef protein of HIV-1 associates with rafts and primes T cells for activation

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Proc Natl Acad Sci U S A. 2000.

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In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin

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Molecular and Cellular Neurosciences. 2000.

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HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

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Nat Cell Biol. 2000.

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Reversal of pathology in the entire brain of mucopolysaccharidosis type VII mice after lentivirus-mediated gene transfer

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Hum Gene Ther. 2000.

A stable system for the high-titer production of multiply attenuated lentiviral vectors

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Mol Ther. 2000.

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Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes

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Mol Ther. 2000.

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A lentiviral vector expressing a fusogenic glycoprotein for cancer gene therapy

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Gene Ther. 2000.

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Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

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Science. 2000.

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The plasma membrane as a combat zone in the HIV battlefield

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Genes Dev. 2000.

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High-level transgene expression in human hematopoietic progenitors and differentiated blood lineages after transduction with improved lentiviral vectors

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Blood. 2000.

Lentivirus gene transfer in murine hematopoietic progenitor cells is compromised by a delay in proviral integration and results in transduction mosaicism and heterogeneous gene expression in progeny cells

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Journal of Virology. 2000.

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Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells

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Blood. 2000.

1999

Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking

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J Virol. 1999.

The Nef protein of primate lentiviruses

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Rev Med Virol. 1999.

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Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors

R. Zufferey; J. E. Donello; D. Trono; T. J. Hope

Journal of Virology. 1999.

The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors

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Immunol Rev. 1999.

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Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes

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Cell. 1999.

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Lentivirus-mediated Bcl-2 expression in betaTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion

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Gene Ther. 1999.

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Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner

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Curr Biol. 1999.

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Transgene expression in the guinea pig cochlea mediated by a lentivirus-derived gene transfer vector

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Hum Gene Ther. 1999.

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The HIV Nef protein alters Ca(2+) signaling in myelomonocytic cells through SH3-mediated protein-protein interactions

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J Biol Chem. 1999.

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1998

Visna virus dUTPase is dispensable for neuropathogenicity

G. Petursson; P. Turelli; S. Matthiasdottir; G. Georgsson; O. Andresson et al.

J Virol. 1998.

Human immunodeficiency virus type 1 matrix protein interacts with cellular protein HO3

J. Lama; D. Trono

J Virol. 1998.

The proteolytic cleavage of human immunodeficiency virus type 1 Nef does not correlate with its ability to stimulate virion infectivity

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J Virol. 1998.

Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes

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When accessories turn out to be essential

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1997

dUTPase-minus caprine arthritis-encephalitis virus is attenuated for pathogenesis and accumulates G-to-A substitutions.

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The multifaceted role of HIV Nef

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Res Virol. 1997.

The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane

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Immunity. 1997.

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Nef and PAK: virulence factor and cellular accomplice

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Chem Biol. 1997.

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The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix

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Second-messenger regulation of receptor association with clathrin-coated pits: a novel and selective mechanism in the control of CD4 endocytosis.

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Mol Biol Cell. 1997.

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Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

R. Zufferey; D. Nagy; R. J. Mandel; L. Naldini; D. Trono

Nat Biotechnol. 1997.

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Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector

U. Blömer; L. Naldini; T. Kafri; D. Trono; I. M. Verma et al.

J Virol. 1997.

Human immunodeficiency virus matrix tyrosine phosphorylation: characterization of the kinase and its substrate requirements

D. Camaur; P. Gallay; S. Swingler; D. Trono

J Virol. 1997.

HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway

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Proc Natl Acad Sci U S A. 1997.

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Nef-mediated clathrin-coated pit formation

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J Cell Biol. 1997.

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1996

Replication properties of dUTPase-deficient mutants of caprine and ovine lentiviruses

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J Virol. 1996.