DPPA2 and DPPA4 are necessary to establish a 2C‐like state in mouse embryonic stem cells

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EMBO reports. 2019-04-04.

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Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs

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Cell Stem Cell. 2019-03-27.

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ZNF445 is a primary regulator of genomic imprinting

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Genes & Development. 2019-01-01.

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Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis

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Mobile Dna. 2018-12-15.

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Pharmacological induction of a progenitor state for the efficient expansion of primary human hepatocytes

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Hepatology. 2018-12-14.

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HIV-1 Vpr and p21 restrict LINE-1 mobility

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Nucleic Acids Research. 2018-07-31.

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KAP1 facilitates reinstatement of heterochromatin after DNA replication

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Nucleic Acids Research. 2018-06-28.

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Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naïve embryonic stem cells

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Epigenetics & Chromatin. 2018-02-26.

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KRAB zinc finger proteins

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Development. 2017.

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A KRABsody for Embryo-Placental Development

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Developmental Cell. 2017.

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DUX-family transcription factors regulate zygotic genome activation in placental mammals

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Nature Genetics. 2017.

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Polyphenic trait promotes liver cancer in a model of epigenetic instability

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Hepatology. 2017.

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The mouse genome displays highly dynamic populations of KRAB-zinc finger protein genes and related genetic units

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PLoS One. 2017.

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KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks

M. Imbeault; P.-Y. Helleboid; D. Trono

Nature. 2017.

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SMiLE-seq identifies binding motifs of single and dimeric transcription factors

A. Isakova; R. Groux; M. Imbeault; P. Rainer; D. Alpern et al.

Nature methods. 2017.

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Switzerland and the Digital Health Revolution

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Chimia. 2016.

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Lentiviral vectors, two decades later

L. Naldini; D. Trono; I. M. Verma

Science. 2016.

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Transposable Elements, Polydactyl Proteins, and the Genesis of Human-Specific Transcription Networks

D. Trono

Cold Spring Harbor symposia on quantitative biology. 2016.

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A Large-Scale Functional Screen to Identify Epigenetic Repressors of Retrotransposon Expression

G. Ecco; H. M. Rowe; D. Trono

Methods in molecular biology (Clifton, N.J.). 2016.

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Molecular Criteria for Defining the Naive Human Pluripotent State

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Cell stem cell. 2016.

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Human Hepatocyte-Derived Induced Pluripotent Stem Cells: MYC Expression, Similarities to Human Germ Cell Tumors, and Safety Issues

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Stem Cells International. 2016.

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Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues

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Developmental Cell. 2016.

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The evolution of gene expression and binding specificity of the largest transcription factor family in primates

A. Kapopoulou; L. Mathew; A. Wong; D. Trono; J. D. Jensen

Evolution. 2016.

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Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages

J.-E. Dietrich; L. Panavaite; S. Gunther; S. Wennekamp; A. C. Groner et al.

EMBO reports. 2015.

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Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch

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eLife. 2015.

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A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation

K. Singh; M. Cassano; E. Planet; S. Sebastian; S. M. Jang et al.

Genes & development. 2015.

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TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells

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Cell Reports. 2015.

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As Time Goes by: KRABs Evolve to KAP Endogenous Retroelements

M. Imbeault; D. Trono

Developmental Cell. 2014.

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Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network

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Elife. 2014.

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Dual-regulated Lentiviral Vector for Gene Therapy of X-linked Chronic Granulomatosis

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Molecular Therapy. 2014.

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Evolutionally dynamic L1 regulation in embryonic stem cells

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Genes & development. 2014.

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Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements

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Genome research. 2014.

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Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency

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Genome research. 2014.

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Control of mitophagie by microRNAs - A key step of erythropoiesis

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M S-Medecine Sciences. 2014.


VEGFR-3 Neutralization Inhibits Ovarian Lymphangiogenesis, Follicle Maturation, and Murine Pregnancy

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American Journal Of Pathology. 2013.

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Prototype Foamy Virus Bet Impairs the Dimerization and Cytosolic Solubility of Human APOBEC3G

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Journal of virology. 2013.

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A switch between topological domains underlies HoxD genes collinearity in mouse limbs

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Science (New York, N.Y.). 2013.

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Global and stage specific patterns of krüppel-associated-box zinc finger protein gene expression in murine early embryonic cells

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PloS one. 2013.

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Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression

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Transl Psychiatry. 2013.

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De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET

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Development (Cambridge, England). 2013.

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TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells

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Genome research. 2013.

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The KRAB-ZFP/KAP1 System Contributes to the Early Embryonic Establishment of Site-Specific DNA Methylation Patterns Maintained during Development

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Cell Reports. 2012.

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KAP1 regulates gene networks controlling T-cell development and responsiveness

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FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012.

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MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant

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The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012.

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Embryonic stem cell potency fluctuates with endogenous retrovirus activity

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Nature. 2012.

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Liver-specific ablation of Krüppel-associated box-associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma

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Hepatology. 2012.

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The Kruppel-associated Box Repressor Domain Can Induce Reversible Heterochromatization of a Mouse Locus in Vivo

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The Journal of biological chemistry. 2012.

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Gene therapy: too much splice can spoil the dish

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The Journal of clinical investigation. 2012.

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KAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function

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Blood. 2012.

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The ATM substrate KAP1 controls DNA repair in heterochromatin: Regulation by HP1 proteins and Serine 473/824 phosphorylation

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Molecular cancer research : MCR. 2012.

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A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow failure syndrome and in vivo in humanized mice

C. Frecha; C. Costa; D. Nègre; F. Amirache; D. Trono et al.

Blood. 2011.

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In Embryonic Stem Cells, ZFP57/KAP1 Recognize a Methylated Hexanucleotide to Affect Chromatin and DNA Methylation of Imprinting Control Regions

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Molecular Cell. 2011.

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A gene-rich, transcriptionally active environment and the pre-deposition of repressive marks are predictive of susceptibility to KRAB/KAP1-mediated silencing

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BMC genomics. 2011.

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Measuring In Vivo Protein Half-Life

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Chemistry & Biology. 2011.

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Lentiviral Vector Mediated Transgenesis

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Current Protocols in Mouse Biology 1. 2011.

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Lineage- and stage-restricted lentiviral vectors for the gene therapy of chronic granulomatous disease

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Gene therapy. 2011.

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Chromosome Conformation Capture Uncovers Potential Genome-Wide Interactions between Human Conserved Non-Coding Sequences

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PloS one. 2011.

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Profaning the Ultimate Sanctuary: HIV Latency in Hematopoietic Stem Cells

D. Trono; F. Marzetta

Cell host & microbe. 2011.

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Genomic instability in induced stem cells

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Cell death and differentiation. 2011.

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Dynamic control of endogenous retroviruses during development

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Virology. 2011.

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Homology-based identification of capsid determinants that protect HIV1 from human TRIM5α restriction

P. V. Maillard; V. Zoete; O. Michielin; D. Trono

The Journal of biological chemistry. 2010.

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A systematic enhancer screen using lentivector transgenesis identifies conserved and non-conserved functional elements at the olig1 and olig2 locus

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PloS one. 2010.

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Structure-function analysis points to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities

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Journal of virology. 2010.

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Inducible Gene and shRNA Expression in Resident Hematopoietic Stem Cells In Vivo

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Stem cells (Dayton, Ohio). 2010.

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Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis pigmentosa

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Science (New York, N.Y.). 2010.

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KRAB-Zinc Finger Proteins and KAP1 Can Mediate Long-Range Transcriptional Repression through Heterochromatin Spreading

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PLoS genetics. 2010.

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The specificity of TRIM5{alpha}-mediated restriction is influenced by its coiled-coil domain

P. V. Maillard; G. Ecco; M. Ortiz; D. Trono

Journal of virology. 2010.

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KAP1 controls endogenous retroviruses in embryonic stem cells

H. M. Rowe; J. Jakobsson; D. Mesnard; J. Rougemont; S. Reynard et al.

Nature. 2010.

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Biosafety in ex vivo gene therapy and conditional ablation of lentivirally transduced hepatocytes in nonhuman primates

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Molecular therapy : the journal of the American Society of Gene Therapy. 2009.

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Innate immunity against retroviral pathogens: from an ambiguous genetic self to novel therapeutic approaches

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Swiss Med Wkly. 2009.

APOBEC3G-depleted resting CD4+ T cells remain refractory to HIV1 infection

F. Santoni de Sio; D. Trono

PLoS One. 2009.

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Functional analysis and structural modeling of human APOBEC3G reveal the role of evolutionarily conserved elements in the inhibition of human immunodeficiency virus type 1 infection and Alu transposition

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Journal of Virology. 2009.

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Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications

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Journal of Virology. 2009.

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Antiprion prophylaxis by gene transfer of a soluble prion antagonist

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The American journal of pathology. 2008.

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KAP1-mediated epigenetic repression in the forebrain modulates behavioral vulnerability to stress

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Neuron. 2008.

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Rescue of a severe mouse model for spinal muscular atrophy by U7 snRNA-mediated splicing modulation

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Hum Mol Genet. 2008.

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Development and characterization of a triple combination gene therapy vector inhibiting HIV-1 multiplication

M. Asparuhova; I. Barde; D. Trono; K. Schranz; D. Schümperli

J Gene Med. 2008.

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A human TRIM5alpha B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus

F. Diaz-Griffero; M. Perron; K. McGee-Estrada; R. Hanna; P. V. Maillard et al.

Virology. 2008.

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Characterization of APOBEC3G binding to 7SL RNA

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Retrovirology. 2008.

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Genotypic features of lentivirus transgenic mice

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APOBEC3-independent interferon-induced viral clearance in hepatitis B virus transgenic mice

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Journal of Virology. 2008.

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Model Structure of Human APOBEC3G

K.-L. Zhang; B. Mangeat; M. Ortiz; V. Zoete; D. Trono et al.

PLoS ONE. 2007.

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Lentivirus as a tool for lineage-specific gene manipulations

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genesis. 2007.

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Molecular mechanism of hepcidin deficiency in a patient with juvenile hemochromatosis

A. Rideau; B. Mangeat; T. Matthes; D. Trono; P. Beris

Haematologica. 2007.

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Inhibition of HIV-1 multiplication by a modified U7 snRNA inducing Tat and Rev exon skipping

M. B. Asparuhova; G. Marti; S. Liu; F. Serhan; D. Trono et al.

The journal of gene medicine. 2007.

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Expression of FGF-2 in neural progenitor cells enhances their potential for cellular brain repair in the rodent cortex

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Brain : a journal of neurology. 2007.

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Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha

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PLOS Pathogens. 2007.

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The KRAB repressor domain can trigger de novo promoter methylation during mouse early embryogenesis

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Journal of Biological Chemistry. 2007.

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Induction of antiviral cytidine deaminases does not explain the inhibition of hepatitis B virus replication by interferons

S. Jost; P. Turelli; B. Mangeat; U. Protzer; D. Trono

J. Virol.. 2007.

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Ataxia-telangiectasia-mutated (ATM) protein can enhance human immunodeficiency virus type 1 replication by stimulating Rev function

Y. Ariumi; D. Trono

Journal of Virology. 2006.

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Ex vivo lentivirus transduction and immediate transplantation of uncultured hepatocytes for treating hyperbilirubinemic Gunn rat

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Multipotential nestin and Isl-1 positive mesenchymal stem cells isolated from human pancreatic islets

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Biochemical and Biophysical Research Communications. 2006.

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Differentiation of Trophoblast Giant Cells and Their Metabolic Functions Are Dependent on Peroxisome Proliferator-Activated Receptor  /

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Molecular and Cellular Biology. 2006.

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A versatile tool for conditional gene expression and knockdown

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Nature Methods. 2006.

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Tuning silence: conditional systems for RNA interference

M. Wiznerowicz; J. Szulc; D. Trono

Nature Methods. 2006.

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Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach

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Diabetologia. 2006.

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KRAB can repress lentivirus proviral transcription independently of integration site

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The Journal of Biological Chemistry. 2006.

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The integrase interactor 1 (INI1) proteins facilitate Tat-mediated human immunodeficiency virus type 1 transcription

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Retrovirology. 2006.


A simple and highly effective method for the stable transduction of uncultured porcine hepatocytes using lentiviral vector

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Cell Transplantation. 2005.

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Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes

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Therapeutic lentivirus-mediated neonatal in vivo gene therapy in hyperbilirubinemic Gunn rats

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Molecular therapy : the journal of the American Society of Gene Therapy. 2005.

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Lentiviral vectors and antiretroviral intrinsic immunity

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Human Gene Therapy. 2005.

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Harnessing HIV for therapy, basic research and biotechnology

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Trends Biotechnol. 2005.

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Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocytes

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Transplant Proc. 2005.

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Editing at the crossroad of innate and adaptive immunity

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DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration

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Novel lentiviral vectors displaying "early acting cytokines" selectively promote survival and transduction of NOD/SCID repopulating human hematopoietic stem cells

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Response to Comment on "Inhibition of Hepatitis B Virus Replication by APOBEC3G"

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Contribution of proteoglycans to human immunodeficiency virus type 1 brain invasion

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The innate antiretroviral factor APOBEC3G does not affect human LINE-1 retrotransposition in a cell culture assay

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Lentiviral vectors interfering with virus-induced CD4 down-modulation potently block human immunodeficiency virus type 1 replication in primary lymphocytes

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Lentivirus-mediated transduction of connexin cDNAs shows level- and isoform-specific alterations in insulin secretion of primary pancreatic beta-cells

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Ectopic expression of the beta-cell specific transcription factor Pdx1 inhibits glucagon gene transcription

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Virology. Picking the right spot.

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Lentivector-mediated transfer of Bmi-1 and telomerase in muscle satellite cells yields a duchenne myoblast cell line with long-term genotypic and phenotypic stability

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Efficient gene transfer into human primary blood lymphocytes by surface-engineered lentiviral vectors that display a T cell-activating polypeptide

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Differentiation of the RN33B cell line into forebrain projection neurons after transplantation into the neonatal rat brain

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Lentiviral vectors pseudotyped with a modified RD114 envelope glycoprotein show increased stability in sera and augmented transduction of primary lymphocytes and CD34+ cells derived from human and nonhuman primates

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Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization

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A lentiviral vector expressing a fusogenic glycoprotein for cancer gene therapy

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Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

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The plasma membrane as a combat zone in the HIV battlefield

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Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors

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Visna virus dUTPase is dispensable for neuropathogenicity

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Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes

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Human immunodeficiency virus matrix tyrosine phosphorylation: characterization of the kinase and its substrate requirements

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